Whether your idea of a vacation getaway is the luxurious boutique hotel experience you'd find at Zero George Street in Charleston, or you'd go gaga over a treehouse rental in the woods near Congaree National Park, there are numerous fun and exciting rentals to choose from in the Palmetto State. To get your creative vacation planning senses all a-tingle, here are some of the most unique places to stay in South Carolina.

Treehouse Rentals in South Carolina

A vacation in a treehouse is one of the most unique experiences you can have. There is nothing more romantic or adventurous than a cozy treehouse rental surrounded by nature. Here is a couple we think you'll really enjoy. They are such fun places to stay in South Carolina!

1. Treehouse by the Sea, Harbour Town

• Address: Harbour Town, SC
• Size: 2 bedrooms (sleeps 4), 2 full baths
• Price: $210/night
• Amenities: Free Wifi, TV, full kitchen, washer & dryer, grill, Japanese soaking tub, community pool
• Ratings: 4.8 stars

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There is something magical about Hilton Head Island as the sun sets on a peaceful day. And this modern treehouse villa is a truly unique way to experience the full effect of this beautiful island. It feels like you are surrounded by an enchanted forest and Nana's treehouse is a secret meeting place for a family of whimsical fairies who will welcome your family with open arms and perhaps a little mischief. With stunning white sand beaches a 15-minute bike ride away, nature walks at the SeaPines Forest Preserve, and abundant wildlife around every corner, this is simply one of the best vacation rentals you will find in South Carolina.

2. Branches Up Tree House, Pickens County

• Address: Harbour Town, SC
• Size: 1 bedroom (sleeps 4), 1 full bath
• Price: $200/night
• Amenities: Kitchenette, heat & air conditioning, fire pit
• Ratings: 4.9 stars

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This cool mountain treehouse sitting on five acres of private land is a delightful way to enjoy a romantic getaway. If you and that special someone enjoy nature walks with gorgeous mountain views you will fit right in. Close to Table Rock State Park, Caesars Head State Park, the Mountain Bridge Wilderness Area, and Jones Gap State Park, you are completely surrounded by the most beautiful areas of South Carolina. If you enjoy unique rentals in South Carolina this one is pretty special.

Tiny Home Rentals in South Carolina

A stay in a tiny house is such a delightful way to spend time with someone you love. And these two tiny home rentals are special each in their own unique way. We hope they tickle your fancy and get you looking forward to a unique getaway.

3. The River Birch, Greenville

• Address: Greenville, SC
• Size: 1 bedroom (sleeps 2), 1 full bath
• Price: $172/night
• Amenities: Free Wifi, TV, kitchenette, heat & air conditioning, fire pit
• Ratings: 5.0 stars

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This charming tiny home community along the Saluda River is a wonderful retreat for couples who yearn to experience tiny house living. The house is spacious, modern, and filled with light. As one of the units on the river itself, you can step off your front porch and enjoy lovely river views, kayaking, and fishing only steps away.

4. Indigo Escape, Daufuskie Island

• Address: Daufuskie Island, SC
• Size: 2 bedrooms (sleeps 4), 1 full bath
• Price: $269/night
• Amenities: Free Wifi, TV, full kitchen, heat & air conditioning, grill, bicycles, waterfront views
• Ratings: 4.9 stars

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This tiny house vacation rental is located in one of the most fun places to stay in South Carolina - you literally have a whole island to explore! Everything is within walking distance in this charming island community, including the lovely historic district, amazing seaside restaurants, white sand beaches, and plenty of hiking trails. You can even rent a golf cart to get around town. Of course, you have your own private dock for boating, fishing, and evenings enjoying the sunset over Calibogue Sound.

Farm Houses for Rent in South Carolina

If your idea of the perfect vacation includes a few donkeys, horses, chickens, and an adorable potbellied pig, we think you'll get a kick out of these two farmhouse rentals in SC.

5. The Bluffton Farmhouse, Old Town Bluffton

• Address: Olde Town, SC
• Size: 2 bedrooms (sleeps 6), 1 full bath
• Price: $300/night
• Amenities: Free Wifi, TV, full kitchen, heat & air conditioning, pet-friendly
• Ratings: 5.0 stars

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This lovely horse farm on a quiet 15 acres outside of Savannah is such a wonderful way to relax and get away from busy city life. Share this wonderful property with horses, a miniature donkey, a potbelly pig, and a pack of rowdy chickens. (Okay, so they are not that rowdy) With a great location for enjoying Old Town Bluffton or a trip to Hilton Head, this quaint farmhouse rental is the perfect home base for exploring the southern tip of South Carolina. Close to several world-class golf courses, Calibogue Sound, and Shelter Cove Harbour.

6. Springwater Farm, Loris

• Address: Loris, SC
• Size: 3 bedrooms (sleeps 6), 2 full baths
• Price: $354/night
• Amenities: Free Wifi, TV, full kitchen, kayak, fishing boat, paddle board, fire pit, pet-friendly
• Ratings: 5.0 stars

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This beautiful farmhouse on its own private spring-fed lake is the perfect getaway for families who want to enjoy the peace and quiet of country living. Swim all day or throw in a line to catch catfish or bass, spend some time in a kayak, or visit the farm animals (who will certainly look for treats). This is simply a cozy retreat where you can wake up, grab some fresh eggs, and enjoy the morning any way you please. You aren't far from Myrtle Beach either, so you can spend a day at the ocean, then return home for some fresh grilled fish you just caught yourself.

Log Cabins for Rent in South Carolina

South Carolina has some of the most beautiful natural areas in the country. And the most immersive experience you'll find is in an authentic log cabin. If you love the outdoors as much as we do, you'll feel right at home in one of these cool log cabin rentals.

7. Historic Log Cabin, Hollywood

• Address: Hollywood, SC
• Size: 1 bedroom (sleeps 5), 1 full bath
• Price: $250/night
• Amenities: Free Wifi, TV, full kitchen, fireplace, grill, kayak, fire pit
• Ratings: 5.0 stars

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This cool old log cabin on the Toogoodoo River near Edisto Island dates back to the 1800s. It is a little slice of rustic cabin living only 20 minutes south of Charleston and a similar distance from Edisto Beach. Spend a day at Botany Bay Beach, go kayaking on the river, or enjoy sitting on the bluffs overlooking the marches around Toogoodoo Creek. You may even see dolphins swimming by your private dock on the water.

8. Secluded Log Cabin, Pickens County

• Address: Hollywood, SC
• Size: 6 bedrooms (sleeps 14), 4 baths
• Price: $293/night
• Amenities: Free Wifi, TV, fully equipped kitchen, washer & dryer, game room, fireplace, grill
• Ratings: 5.0 stars

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This cool multi-family log cabin in the Blue Ridge Mountains is the ultimate outdoor adventure getaway. With close proximity to Table Rock State Park, Lake Jocassee, Devil's Fork State Park, Keowee Key Golf Course, and several breweries and vineyards, you have plenty of options for fun, entertainment, fishing, hiking, horseback riding, and just about any outdoor activity you can imagine. If you are looking for cool places to stay in South Carolina, put this one on your bucket list.

Luxury Beach House Rentals in South Carolina

South Carolina offers some of the most incredible beach houses in the nation. Whether you find a dream home on Sullivan’s Island or a Myrtle Beach mansion, there is nothing like a beach vacation where you can step out your back door and walk right into the ocean.

9. Low Tide Too, Long Bay Estates

• Address: Long Bay Estates, SC
• Size: 6 bedrooms (sleeps 20), 6 baths
• Price: $1,118/night
• Amenities: Gourmet kitchen, washer & dryer, game room, grill, swimming pool
• Ratings: 4.7 stars

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This secluded community next to Myrtle Beach State Park is like an oasis away from the busy summer beaches you'll typically find overrun with tourists. Enjoy the good life with this gorgeous luxury beach house right on the white sand beaches. Floor-to-ceiling windows let you enjoy stunning ocean views that rival the best hotels. Enjoy the best beach life getaway in the state with this luxurious oceanfront rental.

10. Kiawah Beach Mansion, Vanderhorst Plantation

• Address: Vanderhorst Plantation, SC
• Size: 7 bedrooms (sleeps 16), 10 baths
• Price: $3,643/night
• Amenities: Chef's kitchen, washer & dryer, game room, fitness room, grill, private pool, EV charger, private chef
• Ratings: 4.9 stars

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If you desire the best beach house rental in all of South Carolina, this 9,300-square-foot mansion on Kiawah Island is simply a dream. With a private boardwalk to the beach, a private heated swimming pool, and immaculate furnishings, you will enjoy the finest amenities on the island. You'll also enjoy stress-free and delicious meals with your own personal chef.

South Carolina has such wonderful vacation rentals available, from cozy treehouse rentals in Upstate SC to quiet suburban tiny homes in Mount Pleasant, or even large luxurious mansions on the beach. If you are looking for unique places to stay in South Carolina we hope we've given you some inspirational ideas to get you started. Where are your favorite places to stay in South Carolina? Share some of your favorite finds with a comment.