Choosing the right place to stay can make or break your vacation. This is why we’ve come up with some of the best places to stay in South Carolina the next time you want to get away to The Palmetto State. Whether you’re on the hunt for the most affordable accommodations in South Carolina or want to find the most family-friendly vacation rentals in South Carolina, you’ve come to the right place. While you might be more prone to stick to Hilton Head Island and Myrtle Beach, we have a few other overnight suggestions to have you stepping outside the box at a unique Airbnb in South Carolina. From Columbia to Charleston and beyond, ditch the Marriott beach resort and enjoy these Vrbo getaways as well as some of the best Airbnbs in South Carolina.

Best Places to Stay in South Carolina for Families

Oftentimes the best places to stay in South Carolina are perfect for families. There are also, plenty of family-friendly adventures worth exploring in South Carolina. Whether the rental includes a pool, some family-friendly attraction, or otherwise, South Carolina has some pretty incredible places to stay with the whole brood.

1. Watertree Sunsets, Camden

• Location: Camden, SC
• Size: 3 bedrooms (sleeps 8), 2 full baths
• Price: $189/night
• Amenities: lakefront, fire pit, dedicated workspace, game table, washer & dryer, propane grill
• Rating: 5 stars

[affiliatelink url="https://www.airbnb.com/rooms/812538859592147386"]More Info and Photos[/affiliatelink]

This is a gorgeous lakefront home where you can enjoy lake views, kayaking, swimming, fishing, and more. Relax by the water or go play in it. You’ll have fast wi-fi available and a wonderful sauna. There’s a 62” Roku TV and a full kitchen as well as a high chair and children’s toys. This place truly is perfect for a family vacation and you’ll want to come back again.

2. Cheerful 3-Bedroom Home on the Lake, Summerton

• Location: Summerton, SC
• Size: 3 bedrooms (sleeps 6), 2 full baths
• Price: $159/night
• Amenities: dock, deck with grill, 65” smart TV, washer & dryer, hammock, boat slip
• Rating: 5 stars

[affiliatelink url="https://www.airbnb.com/rooms/52422651"]More Info and Photos[/affiliatelink]

This is a homey stay on the lake has a screened porch and a private dock where you can bring a boat, jet ski, or kayak to enjoy some play time on the water. There’s a full kitchen and outdoor grill so you can cook up a feast any way you like. Lounge in the hammock or go for a swim. There’s so much to enjoy about this amazing family stay.

3. The Lucky Penny, Isle of Palms

• Location: Isle of Palms, SC
• Size: 7 bedrooms (sleeps 16), 6 baths
• Price: $1,259/night
• Amenities: Wi-Fi, fully stocked kitchen, game room, swimming pool, hot tub, game room, jacuzzi tub, private chef
• Rating: 5.0 stars

[affiliatelink url="https://www.vrbo.com/2653402"]More Info and Photos[/affiliatelink]
If you are going to take the family on a trip to South Carolina you may as well enjoy your stay to the fullest. The Lucky Penny is a beautiful home with all the amenities you could ask for. There is plenty of room for a multi-family getaway if you want to bring all your friends and family members too. Lounge around the salt-water swimming pool or walk to the beach, either way the warm South Carolina sun is ready to make your beach vacation a memorable one. With a number of golf courses, beaches, fishing piers, and restaurants in the area there is something for everyone.

4. Singing Pins Cottage, Seneca

• Location: Seneca, SC
• Size: 3 bedrooms (sleeps 6), 2 full baths
• Price: $146/night
• Amenities: Wi-Fi, washer & dryer, A/C & heating, children’s books & toys, board games, full kitchen
• Rating: 5 stars

[affiliatelink url="https://www.airbnb.com/rooms/829082448100902344"]More Info and Photos[/affiliatelink]

This is a comfy and spacious cottage in Seneca just five minutes from Ram Cat Alley and a few minutes from three different lakes. You’ll enjoy this clean and comfortable home and your kids will enjoy the games, toys, and books that are provided here. It’s a wonderful home base from which to explore nearby waterfalls, hiking trails, and amazing Southern BBQ.

Best Affordable Places to Stay in South Carolina

If you're the type of traveler who would prefer to prioritize activities over accommodations, like taking to the golf course over posh linens, you don't need to settle. Some of the most affordable vacation rentals in South Carolina also offer character and fun, too. Sometimes the best hotels can be a bit costly. Like that boutique hotel, you've been eyeing in historic Charleston. But just because you find a rental within a budget doesn't mean it's boring! Don't sacrifice comfort or excitement when choosing where to stay in South Carolina because these rentals are low cost but big fun. There are many ways to stretch your dollar and have fun in South Carolina.

5. The Boho Barndo, Moncks Corner

• Location: Moncks Corner, SC
• Size: 1 bedroom (sleeps 4), 1 full bath
• Price: $105/night
• Amenities: gated, washer & dryer, 50” HDTV, A/C & heating, full kitchen
• Rating: 5 stars

[affiliatelink url="https://www.airbnb.com/rooms/1069578378298241854"]More Info and Photos[/affiliatelink]

This unique Airbnb in South Carolina is on a gated property on five acres of land. It’s about 20 minutes from downtown Summerville and it’s a lovely location that you’re sure to enjoy. With a full kitchen, a TV with Amazon Fire, and a rustic barn feel with boho decor, you’ll love the peace and quiet of this hip accommodation. You’re sure to give it yet another 5-star review!

6. Centrally Located Home - Florence County

• Location: Florence County, SC
• Size: 3 bedrooms, 2 bathrooms (Sleeps 6)
• Price: $140/night
• Amenities: Single-family home, full kitchen, internet, games, smart TV, washer and dryer
• Ratings: 5 stars

[affiliatelink url="https://www.vrbo.com/2848490"]More Info and Photos[/affiliatelink]
You won’t break the bank when renting this affordable place to stay in Florence County, South Carolina. With a perfect rating of 5/5, it’s easy to see why so many visitors found comfort here. Settle in for an evening on the couch to catch up on your favorite shows. Or gather everyone in the kitchen for a family-friendly meal!

7. Congaree Vines Woodland Cottage, Gaston

• Location: Gaston, SC
• Size: 2 bedrooms (sleeps 4), 1 full bath
• Price: $86/night
• Amenities: vineyard, pet-friendly, fire pit, hammock, outdoor seating, grill
• Rating: 4.9 stars

[affiliatelink url="https://www.airbnb.com/rooms/30061825"]More Info and Photos[/affiliatelink]

This is a charming vineyard cottage where you can not only stroll through the vineyard but sample some of its wines. There’s a small kitchen with a two-burner stove, mini-fridge, toaster oven, microwave, and dishes and cookware are available. Have a cookout on the grill and enjoy lounging under the stars in a hammock! The reviews of this place are extremely favorable.

Best Romantic Places to Stay in South Carolina for Couples

Ahh, a romantic southern getaway. What better place to create the ultimate anniversary weekend than a state bursting with charm, culture, and history? Finding the right romantic accommodation in South Carolina doesn't need to be difficult. All you need is a little privacy and a weekend open for possibility. But what could be more romantic than some oceanfront accommodations with views of the Atlantic and a Lowcountry hideaway on Lake Murray?

8. Lake Murray Retreat - Leesville

• Location: Leesville, SC
• Size: 3 bedrooms, 2 bathrooms (Sleeps 6)
• Price: $384/night
• Amenities: Lake access, deck, fire pit, full kitchen, boat ramp, private dock, beach
• Ratings: 4.9 stars

[affiliatelink url="https://www.vrbo.com/9532701ha"]More Info and Photos[/affiliatelink]
Just because this one sleeps six people doesn’t mean all of them need to come! Imagine having this Lake Murray vrbo rental all to yourself, no kids, no family members included. As one of the most romantic rentals on the lake, you’ll be able to have fires at night waterside, sit in the sand during the day, and relax in your very own slice of paradise.

9. Oceanfront Condo - Seaside Beach

• Location: Surfside Beach, SC
• Size: 2 bedrooms, 2 bathrooms (Sleeps 6)
• Price: $144/night
• Amenities: Oceanfront, first-floor, sunset views, free wireless internet, Smart TV, private balcony
• Ratings: 4.8 stars

[affiliatelink url="https://www.vrbo.com/476193"]More Info and Photos[/affiliatelink]
Nothing says romance quite like an oceanfront condo. Oftentimes the best places to stay in South Carolina offer sunrise views like no other. Here at Surfside Beach, you and your partner can relax on your private balcony, listening to the soothing sounds of the waves. Imagine immediately walking out of your first-floor oceanfront resort condo and hitting the beach. It doesn’t get much better than oceanfront accommodations within walking distance of the Atlantic Ocean.

10. Sassafras Cabin, Pickens County

• Location: Pickens County, SC
• Size: 1 bedroom (sleeps 2), 1 full bath
• Price: $89/night
• Amenities: hot tub, indoor gas fireplace, linens & towels, A/C & heating, full kitchen
• Rating: 4.8 stars

[affiliatelink url="https://www.airbnb.com/rooms/52495688"]More Info and Photos[/affiliatelink]

This is a cozy little cabin in the Jocassee Gorges Wilderness on 6 acres and it’s a sweet and romantic little getaway. There’s a full kitchen inside to make a romantic dinner and a hot tub behind the cabin to soak in. Cozy up in front of the gas fireplace and lounge on the private patio with spectacular views. You’ll adore this cute cabin and its grill area with outdoor furniture.

Best Places to Stay in Charleston

If you're a vacationer who prefers history and character over a cabin in the woods, head on to the quaint city of Charleston. Situated right on the coast, Charleston is a gem worth spending a weekend exploring. Families can enjoy the walkable streets and proximity to the beach. Meanwhile, couples can enjoy romantic dinners and waterfront accommodations.

11. Serene Garden Cottage - Charleston

• Location: Charleston, SC
• Size: 1 bedroom, 2 bathrooms (Sleeps 4)
• Price: $405/night
• Amenities: Saltwater pool, koi ponds, French doors, off-street parking
• Ratings: 4.7 stars

[affiliatelink url="https://www.vrbo.com/68057"]More Info and Photos[/affiliatelink]
Let’s say it might not get much better than a serene cottage in Charleston with an incredible garden AND heated pool. Push all your worries to the wayside when you spend the night in this delightful home with enough space to comfortably sleep four people. This one might not feel like it’s an accommodation in South Carolina, especially when you see the koi pond, water lilies, salt water pool, or beautiful garden. Located in the Cannonborough-Elliotborough neighborhood, this is the perfect rental to get away from it all.

12. Downtown Loft - Charleston

• Location: Charleston, SC
• Size: 1 bedroom, 1 bathroom (Sleeps 5)
• Price: $192/night
• Amenities: Lofted ceilings, full kitchen, hardwood floors, stainless steel appliances, a sleeper sofa
• Ratings: 4.7 stars

[affiliatelink url="https://www.vrbo.com/2127289"]More Info and Photos[/affiliatelink]
Have you ever wanted to stay in your very own Downtown Charleston loft? You’re in luck because this gem in the heart of the French Quarter has it all. Perhaps the most charming aspect of this loft is the spiral staircase to the lofted bedroom, but that’s only scratching the surface in terms of amenities. With the ability to sleep six people comfortably, you’ll enjoy the southern beauty of this historic hideaway every day of your stay.

13. The Monroe on Spring, Cannonborough Elliotborough

• Location: Charleston, SC
• Size: 5 bedrooms (sleeps 16), 5 full baths
• Price: $1,522/night
• Amenities: Wi-Fi, full kitchen, fireplace, washer & dryer, heat & air conditioning
• Rating: 4.9 stars

[affiliatelink url="https://www.vrbo.com/2076023"]More Info and Photos[/affiliatelink]
Elegantly appointed, The Monroe on Spring is a historic Charleston Manor that was built in 1885. This iconic home has been lovingly restored and is only missing one thing - your family. Charleston is a delightful city and you will be swept off your feet both with this charming manor and with the welcoming town. Visit the iconic King Street in the heart of downtown Charleston for cute shops, fine dining, and that beautiful southern charm you came to South Carolina for.

14. Porch Paradise at Oyster Pointe, Charleston

• Location: Charleston, SC
• Size: 2 bedrooms (sleeps 4), 1 full bath
• Price: $164/night
• Amenities: downtown location, king & queen beds, off-street parking, 3 private porches
• Rating: 4.9 stars

[affiliatelink url="https://www.airbnb.com/rooms/48809043"]More Info and Photos[/affiliatelink]

This is a wonderful downtown stay in a Victorian style that was built in 1935. It oozes history and charm and it’s quite close to famous restaurants like Chubby Fish and Chez Nous. It’s spacious and comfy and the full kitchen and bathroom have everything you’ll need. It’s a perfect place from which to explore the best of Charleston.

Best Places to Stay in Columbia

There's no better way to see the beauty of South Carolina than with a visit to the capital city itself. Columbia offers so much in the way of beauty - whether it's the historic district brick buildings or the quaint mom-and-pop shops. Some of the best places to stay in South Carolina can be found in this charming city, and they don't include luxury hotels.

15. Outdoor Paradise - Columbia

• Location: Columbia, SC
• Size: 2 bedrooms, 1 bathroom (Sleeps 4)
• Price: $163/night
• Amenities: Outdoor amenities, heated patio, fire pits, full kitchen, screened-in porch, wheelchair-accessible ramp, ADA-compliant bathroom
• Ratings: 5 stars

[affiliatelink url="https://www.vrbo.com/9637656ha"]More Info and Photos[/affiliatelink]
This hidden gem in Columbia, South Carolina, is perfect for families in town checking out the local football games. Not only do you have close proximity to everything in town, but you also have amenities in this Vrbo that will make you feel right at home. Enjoy the screened-in porch for late-night lounging or the backyard fire pit for marshmallows and more. Plus, this home boasts a wheelchair-accessible ramp as well as ADA compliant bathroom!

16. The Blue Door Farmhouse, Columbia

• Location: Columbia, SC
• Size: 2 bedrooms (sleeps 5), 1 full bath
• Price: $99/night
• Amenities: fenced backyard, den w/ pull-out sofa, 2 queen bedrooms, off-street parking
• Rating: 4.9 stars

[affiliatelink url="https://www.airbnb.com/rooms/31363281"]More Info and Photos[/affiliatelink]

This is a cozy little home in the lovely Earlewood Park neighborhood of Columbia and it was built over 100 years ago! It was moved to this location during the 1940s and is full of charm and comfort. It has a dedicated workspace, a washer & dryer, a full kitchen, and exterior security cameras for a wonderful and safe stay. Linens and towels are provided and if you like it you can even stay long-term!

17. Hampton Forest Home, Columbia

• Location: Columbia, SC
• Size: 2 bedrooms (sleeps 4), 2.5 baths
• Price: $129/night
• Amenities: dedicated workspace, Roku HDTV, washer & dryer, A/C & heating, full kitchen
• Rating: 4.9 stars

[affiliatelink url="https://www.airbnb.com/rooms/52667974"]More Info and Photos[/affiliatelink]

This is a spacious and charming home with wooden floors, comfortable furnishings, homey decor, and it’s just minutes away from excellent shops and restaurants. There are two private bedroom suites, one with a king bed and one with a queen. There’s a full kitchen and the whole place is a lovely mixture of luxury and old-fashioned charm. You’ll love coming back here after exploring beautiful Columbia.

Have you already visited or stayed at any of these vacation rentals in South Carolina? Which places do you think are the best places to stay in South Carolina? Share with us your favorites in the comments section! Or, if you already know the best places to stay in South Carolina according to your travels, make sure to shout those out, too! If you're looking for amazing places, check out these waterfront Airbnbs in South Carolina:

https://www.onlyinyourstate.com/south-carolina/warm-weather-waterfront-getaways-sc/